Medicinal chemistry – Page 3
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ResearchHow HIV drugs have changed over the decades
From one big pill that only prolonged lives a few months, through the 20 pills a day years to modern combination therapies, treating HIV is a science success story
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OpinionLab automation gives me more time at the top of the mountain
Getting back to the bench reminds Derek Lowe how much has changed in 40 years
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ResearchScreening reveals thousands of ‘undrugged, yet druggable’ proteins
Collaboration involving Pfizer develops freely accessible AI tool to probe protein–compound interactions
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ResearchNew mechanism identified that is potentially linked to very early stages of Alzheimer’s
Understanding role of fragments of amyloid protein could lead to novel therapies for the disease
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NewsExplainer: nitazenes and xylazine – a cause for concern
Why is the use of these highly potent synthetic drugs rising dramatically?
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ResearchCould mechanochemistry have saved Abbott Laboratories $250 million?
Ball milling solves problem of disappearing ritonavir polymorph
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ResearchCross-coupling technique cracks open alcohols for chemical synthesis
A new alcohol–alcohol cross coupling reaction could become a powerful new tool for synthetic chemists
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ResearchNon-antibiotics with antibacterial activity could help in the fight against antimicrobial resistance
New analysis shows that non-antibiotic drugs kill bacteria through mechanisms that differ from those of conventional antibiotics
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OpinionHarnessing biodiversity through natural products research in the Philippines
Collaborative projects aim to produce cheaper and more effective medicines
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FeatureHow microbes influence our brain health
Our gut microbiome has been linked to conditions such as Parkinson’s and Alzheimer’s. Anthony King reports on the connections
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OpinionFrom one sinking ship to another?
Biogen abandoning Alzheimer’s antibody aducanumab is unusual, but hardly surprising, says Derek Lowe
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BusinessBig deals confirm renewed interest in radiopharmaceuticals
Acquisitions of RayzeBio and Point Biopharma highlight the potential of targeting radioactivity directly to tumour cells
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ResearchPre-organising antibiotic structure could aid fight against resistance
Strategy that produced new antibiotic could allow researchers to repurpose existing antibiotics
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BusinessNovo Holdings to buy contract manufacturer Catalent for $16.5 billion
Parent firm will then sell on three manufacturing sites to Novo Nordisk to boost capacity for diabetes and weight loss drugs
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FeatureMore than a mirror-image: left-handed nucleic acids
Now a biological reality, researchers are starting to figure out the many roles of left-handed nucleic acids such as Z-DNA – from immunity to controlling our genetics. Rachel Brazil reports
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ResearchHeavy metals are potential ovarian toxicants
Exposure to metals like arsenic, cadmium and mercury linked to reduced egg production, earlier menopause for middle-aged women
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ResearchRare medical transmission of Alzheimer’s disease from donor to patient discovered
Human growth hormone extracted from cadavers passed disease protein to at least five people
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ResearchUnravelling enzyme pathway of Taxol precursor brings synthetic production of cancer medicine closer
Expression of nine genes in tobacco plants led to formation of complex precursor of drug
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ResearchPFAS linked to foetal metabolism disorders
‘Forever chemicals’ in the livers of unborn children can alter lipid metabolism and may increase the risk of metabolic disease in adulthood