Cinchona plant alkaloid catalyst subtracts hydrogen to invert alcohols’ chirality

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Blue light desymmetrisation of diols holds promise for drug synthesis

Hydrogen atoms can be selectively extracted from symmetrical molecules using a catalyst readily derived from Cinchona alkaloids, researchers in the UK have shown. The researchers went on to form carbon–carbon bonds using the resulting chiral radicals. They believe the work could potentially have widespread applications in pharmaceuticals and other fields of synthetic chemistry.