Light-driven method simplifies synthesis of complex heterocycles

A new photochemical method enables precise rearrangement of thiazoles and isothiazoles, providing new synthetic routes for complex azole derivatives.

Typically, thiazole and isothiazole derivatives are generated using multi-step synthetic strategies that require extensive preparation of functionalised precursors. These traditional methods often struggle to access certain structural isomers, produce low yields and involve complex reaction conditions.