Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchAI tool learns to build molecules fragment by fragment
Software tasked with designing a type-II kinase inhibitor suggests 97 candidates in 10 minutes, three of which were both synthesisable and effective at micromolar and nanomolar concentrations
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BusinessEurope reconsiders Alzheimer’s antibody approval
Leqembi recommended for approval with restrictions to reduce side effect risk
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ResearchFirst detected 40 years ago, a byproduct in chloraminated drinking water has finally been identified
Researchers call for urgent investigation into the chloronitramide anion’s toxicity
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OpinionDo chemists die young?
Death notices for chemists suggest perhaps not, despite the hazards found in many labs
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ResearchCyclopropyl effect causes substituents on cyclohexane to favour axial conformation
‘Unusual stereocontrol element’ will help medicinal chemists increase three-dimensionality of drug candidates
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ResearchA new gold standard in selective nitrobenzene hydrogenation
Reaction proceeds through a previously unidentified mechanism
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NewsmicroRNA discovery wins Nobel prize in medicine
Research on tiny RNA molecules unlocked mysteries of gene regulation and cell differentiation
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BusinessUS approves schizophrenia drug with new mode of action
Cobenfy promises to better address negative symptoms than existing antipsychotics
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WebinarEmerging routes to new therapeutics: Highlights from winning Horizon Prize teams
Discover how new therapeutics have the potential to address unmet medical needs
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WebinarThe science and promise of liquid biopsies: improving cancer treatment
Join us on 4 December to learn how liquid biopsies are being used to identify cancer and improve patient outcomes
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OpinionA chemist in the flower garden
The beautifully complex molecules plants produce are as inspiring as the blooms themselves
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FeatureBlood biopsies for cancer
Testing small amounts of blood for the presence of disease markers could revolutionise how we detect cancer. Clare Sansom reports
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ResearchYellow food dye could give doctors a new way to look beneath the skin
Tartrazine can safely and reversibly turn the skin of mice transparent
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BusinessTea tree oil faces ban in UK and EU over reprotoxicity
Defenders question relevance of animal safety data that triggered decision
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BusinessUS industry braced for change as election looms
Regulation, trade tariffs and innovation support top lists of concerns
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OpinionBeing wrong is almost inevitable
On the tightrope of expressing your opinion, you always risk looking a fool
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OpinionGLP-1 drugs could be more than a win–win for weight loss
Semaglutide and tirzepatide are changing lives, and could change our attitudes
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FeatureThe GLP-1 weight loss revolution
Glucagon-like peptide-1 agonist drugs, such as semaglutide, could save countless lives at risk due to diabetes and obesity. Rachel Brazil looks at the difficulties in making the peptides themselves, and what’s coming next